Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00NXM
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| Former ID |
DIB002035
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| Drug Name |
GSK-2251052
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| Synonyms |
ABX; AN-3365; GSK '052; Boron-based LeuRS inhibitors (Gram-negative bacterial infection), Anacor/GSK; Boron-based leucyl-tRNA synthetase inhibitors (bacterial infection), Anacor/GSK
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| Drug Type |
Small molecular drug
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| Indication | Urinary tract infection [ICD-11: GC08; ICD-10: N39, N39.0; ICD-9: 599] | Phase 2 | [1] | |
| Company |
Anacor Pharmaceuticals Inc
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| Structure |
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Download2D MOL
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| Formula |
C11H16BNO4
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| Canonical SMILES |
B1(C2=C(C=CC=C2OCCCO)C(O1)CN)O
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| InChI |
1S/C11H16BNO4/c13-7-10-8-3-1-4-9(16-6-2-5-14)11(8)12(15)17-10/h1,3-4,10,14-15H,2,5-7,13H2/t10-/m1/s1
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| InChIKey |
FXQIIDINBDJDKL-SNVBAGLBSA-N
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| CAS Number |
CAS 1093643-37-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Staphylococcus Leucyl-tRNA synthetase (Stap-coc leuS) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01381549) GSK2251052 in Complicated Urinary Tract Infection. U.S. National Institutes of Health. | |||
| REF 2 | Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. | |||
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