Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00NSM
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| Former ID |
DIB010546
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| Drug Name |
CM-GLP-1
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| Synonyms |
CellBead Neuro; GLP-1-expressing stem cell therapy (drug eluting bead, neurological trauma/neurodegeneration); CM-1-expressing stem cell therapy (drug eluting bead, neurological trauma/neurodegeneration), CellMed; GLP-1-expressing stem cell therapy (drug eluting bead, neurological trauma/neurodegeneration), CellMed
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| Indication | Brain injury [ICD-11: NA07.Z] | Discontinued in Phase 1/2 | [1] | |
| Company |
CellMed AG
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon-like peptide 1 receptor (GLP1R) | Target Info | Modulator | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Insulin secretion | ||||
| Reactome | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | |||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023519) | |||
| REF 2 | Reversal of diabetes in rats using GLP-1-expressing adult pancreatic duct-like precursor cells transformed from acinar to ductal cells. Stem Cells Dev. 2009 Sep;18(7):991-1002. | |||
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