Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00NKB
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| Former ID |
DAP000575
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| Drug Name |
Triamterene
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| Synonyms |
Ademin; Ademine; Amteren; Anjal; Dazid; Diarol; Dinazide; Diren; Ditak; Diucelpin; Diurene; Diutensat; Diuteren; Dyberzide; Dyren; Dyrenium; Dytac; Dytenzide; Esiteren; Hidiurese; Hydrene; Hypertorr; Isobar; Jatropur; Jenateren; Kalspare; Masuharmin; Nephral; Noridil; Noridyl; Pterofen; Pterophene; Renezide; Reviten; Taturil; Teriam; Teridin; Triamizide; Triampur; Triamteren; Triamterena; Triamterenum; Triamteril; Triamterine; Triamthiazid; Tricilone; Trispan; Triteren; Triurene; Trizid; Turfa; Uretren; Urocaudal; Goldshield Brand of Triamterene; Jorba Brand of Triamterene; Pter ophene; SmithKline Beecham Brand of Triamterene; TRIAMTERENE USP; Thiazid Wolff; Triamteril complex; Wellspring Brand of Triamterene; Fluss 40; SKF 8542; T 4143; Ademin(e); Apo-triazide; Dyrenium (TN); Pteridine deriv. 11; SALI-PUREN; SK&F 8542; SK-8542; Tri-Span; Triamterena [INN-Spanish]; Triamterenum [INN-Latin]; SK&F-8542; Triamterene (JP15/USP/INN); Triamterene [USAN:INN:BAN:JAN]; 2,4,7-Triamino-6-fenilpteridina; 2,4,7-Triamino-6-fenilpteridina [Italian]; 2,4,7-Triamino-6-phenylpteridine; 6-PHENYL-2,4,7-TRIAMINO PTERIDINE; 6-Phenyl-2,4,7-pteridinetriamine; 6-Phenyl-2,4,7-triaminopteridine; 6-phenylpteridine-2,4,7-triamine
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| Drug Type |
Small molecular drug
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| Indication | Congestive heart failure [ICD-11: BD10; ICD-10: I50.0] | Approved | [1], [2], [3] | |
| Edema [ICD-11: MG29; ICD-10: R60] | Approved | [1], [2], [3] | ||
| Hypertension [ICD-11: BA00-BA04] | Approved | [1], [2], [3] | ||
| Therapeutic Class |
Diuretics
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| Structure |
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Download2D MOL |
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| Formula |
C12H11N7
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| Canonical SMILES |
C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N
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| InChI |
1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
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| InChIKey |
FNYLWPVRPXGIIP-UHFFFAOYSA-N
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| CAS Number |
CAS 396-01-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
118408, 602599, 855896, 933823, 5660597, 7847452, 8036221, 8149565, 8153414, 10321477, 11111878, 11111879, 11335608, 11360847, 11363402, 11365964, 11368526, 11372243, 11373970, 11376688, 11452214, 11461819, 11466062, 11467182, 11484612, 11485784, 11488754, 11491187, 11492181, 11494322, 14774401, 17389703, 17405750, 24277877, 26611958, 26679801, 26747035, 26751552, 29224587, 46507623, 47291080, 47588940, 47662218, 47662219, 47810690, 47885351, 47885352, 47959674, 48035047, 48334426
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| ChEBI ID |
CHEBI:9671
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| ADReCS Drug ID | BADD_D02275 | |||
| SuperDrug ATC ID |
C03DB02
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| SuperDrug CAS ID |
cas=000396010
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Amiloride-sensitive sodium channel (ENaC) | Target Info | Blocker | [4] |
| KEGG Pathway | Taste transduction | |||
| Aldosterone-regulated sodium reabsorption | ||||
| Pathwhiz Pathway | Kidney Function | |||
| Reactome | Stimuli-sensing channels | |||
| WikiPathways | Nuclear Receptors Meta-Pathway | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4329). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071251. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis. Cell Physiol Biochem. 2001;11(4):209-18. | |||
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