Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00LBX
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| Former ID |
DNC000319
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| Drug Name |
Bicuculline
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| Synonyms |
(+)-Bicuculline; bicuculline; d-Bicuculline; 485-49-4; Bicculine; Bicucullin; Bicuculline (+); UNII-Y37615DVKC; NSC 32192; C20H17NO6; EINECS 207-619-7; BRN 0098786; CHEMBL417990; CHEBI:3092; Y37615DVKC; (6R)-6-[(5S)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one; NSC32192; Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H17NO6
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| Canonical SMILES |
CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
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| InChI |
1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
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| InChIKey |
IYGYMKDQCDOMRE-ZWKOTPCHSA-N
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| CAS Number |
CAS 485-49-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11555, 90838, 3151977, 7978788, 8138145, 8149737, 8157382, 10321197, 11335784, 11361023, 11461995, 11466617, 11467737, 11486393, 15953321, 24848584, 29228758, 47736466, 47810739, 47810740, 47959732, 48035105, 48184980, 48259218, 48259219, 48334478, 49698571, 49746882, 49971723, 50557195, 53789175, 56311924, 56463577, 57326063, 61282576, 85305365, 88771100, 92125404, 92303463, 99301697, 103177562, 103913677, 103915241, 104322745, 118046944, 118055390, 121363075, 124559143, 124559289, 124749560
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| ChEBI ID |
CHEBI:3092
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| SuperDrug ATC ID |
A02BC05
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| SuperDrug CAS ID |
cas=161973100
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gamma-aminobutyric acid receptor (GAR) | Target Info | Antagonist | [2] |
| Glutamate receptor AMPA (GRIA) | Target Info | Antagonist | [3] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2312). | |||
| REF 2 | GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala. J Neurosci. 1999 Nov 15;19(22):9698-704. | |||
| REF 3 | Effects of subcutaneous administration of the gamma-aminobutyric acid(A) receptor agonist muscimol on water intake in water-deprived rats. Physiol Behav. 2002 Nov;77(2-3):445-50. | |||
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