Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00JGL
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| Former ID |
DIB019066
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| Drug Name |
D-4476
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| Synonyms |
CK1 inhibitor; D 4476
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| Drug Type |
Small molecular drug
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| Indication | Chronic lymphocytic leukaemia [ICD-11: 2A82.0; ICD-10: C83.0, C91.1] | Preclinical | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C23H18N4O3
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| Canonical SMILES |
C1COC2=C(O1)C=CC(=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
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| InChI |
1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
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| InChIKey |
DPDZHVCKYBCJHW-UHFFFAOYSA-N
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| CAS Number |
CAS 301836-43-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10318965, 11618425, 14903499, 26758401, 26758404, 43014019, 53800834, 78193318, 85787680, 99302657, 103567655, 104098224, 114518093, 121514413, 124950699, 125333838, 135653405, 135698763, 136208120, 162021971, 162022472, 162248207, 162832939, 163620699, 163686014, 163688432, 163688435, 163781279, 163883074, 164046266, 174006679, 175426319, 175607464, 175607701, 178102563, 180096573, 186007029, 208265044, 223384990, 223704981, 225106566, 226705451, 241376158, 242060325, 250136920, 251920432, 251971225, 252156862, 252215234, 252436152
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| ChEBI ID |
CHEBI:91448
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Casein kinase I alpha (CSNK1A1) | Target Info | Inhibitor | [2] |
| Casein kinase I delta (CSNK1D) | Target Info | Inhibitor | [3] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307. | |||
| REF 2 | Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization. Eur J Med Chem. 2012 Oct;56:30-8. | |||
| REF 3 | The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. | |||
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