Drug Information
Drug General Information | Top | |||
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Drug ID |
D00ISN
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Former ID |
DIB015980
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Drug Name |
MT-1303
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Drug Type |
Small molecular drug
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Indication | Crohn disease [ICD-11: DD70; ICD-10: K50, K50.9; ICD-9: 555] | Phase 2 | [1] | |
Multiple sclerosis [ICD-11: 8A40; ICD-9: 340] | Phase 2 | [2] | ||
Company |
Mitsubishi Tanabe Pharma Corp
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Structure |
Download2D MOL
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Formula |
C19H31ClF3NO3
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Canonical SMILES |
CCCCCCCOC1=C(C=C(C=C1)CCC(CO)(CO)N)C(F)(F)F.Cl
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InChI |
1S/C19H30F3NO3.ClH/c1-2-3-4-5-6-11-26-17-8-7-15(12-16(17)19(20,21)22)9-10-18(23,13-24)14-25;/h7-8,12,24-25H,2-6,9-11,13-14,23H2,1H3;1H
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InChIKey |
GEDVJGOVRLHFQG-UHFFFAOYSA-N
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CAS Number |
CAS 942398-84-7
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Sphingosine-1-phosphate receptor 1 (S1PR1) | Target Info | Modulator | [3] |
KEGG Pathway | FoxO signaling pathway | |||
Sphingolipid signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
NetPath Pathway | IL4 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
IL2 Signaling Pathway | ||||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
S1P3 pathway | ||||
S1P1 pathway | ||||
Sphingosine 1-phosphate (S1P) pathway | ||||
PDGFR-beta signaling pathway | ||||
Reactome | G alpha (i) signalling events | |||
Lysosphingolipid and LPA receptors | ||||
WikiPathways | Signal Transduction of S1P Receptor | |||
Small Ligand GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 2 | ClinicalTrials.gov (NCT01890655) Extension Study of MT-1303. U.S. National Institutes of Health. | |||
REF 3 | Sphingosine 1-Phosphate Receptor Modulators in Multiple Sclerosis. CNS Drugs. 2015 Jul;29(7):565-75. |
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