Drug Information
Drug General Information | Top | |||
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Drug ID |
D00HAJ
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Former ID |
DNC006887
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Drug Name |
Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C49H63FN10O9
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Canonical SMILES |
CC(C)CCC(C(=O)NC(CC1=CC=C(C=C1)F)C(=O)NC(CC2=CC=CC=C2)C(=O)N)NC(=O)C3CCCN3C(=O)C(CCCN)NC(=O)C(CC4=CC=CC=C4)NC(=O)C5CC(=O)NC(=O)N5
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InChI |
1S/C49H63FN10O9/c1-29(2)17-22-34(43(63)56-38(27-32-18-20-33(50)21-19-32)45(65)55-36(42(52)62)25-30-11-5-3-6-12-30)53-47(67)40-16-10-24-60(40)48(68)35(15-9-23-51)54-44(64)37(26-31-13-7-4-8-14-31)57-46(66)39-28-41(61)59-49(69)58-39/h3-8,11-14,18-21,29,34-40H,9-10,15-17,22-28,51H2,1-2H3,(H2,52,62)(H,53,67)(H,54,64)(H,55,65)(H,56,63)(H,57,66)(H2,58,59,61,69)/t34-,35-,36+,37-,38-,39-,40-/m0/s1
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InChIKey |
HXKFHHNEFCZKPG-VEKZNEBUSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Melanocortin receptor 4 (MC4R) | Target Info | Inhibitor | [1] |
Substance-K receptor (TACR2) | Target Info | Inhibitor | [1] | |
Vasopressin V1a receptor (V1AR) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Vascular smooth muscle contraction | ||||
Pathway Interaction Database | Syndecan-3-mediated signaling events | |||
Reactome | G alpha (q) signalling events | |||
Vasopressin-like receptors | ||||
Peptide ligand-binding receptors | ||||
G alpha (s) signalling events | ||||
WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | |||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Class A Rhodopsin-like |
References | Top | |||
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REF 1 | Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. |
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