Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00EPT
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| Former ID |
DNCL002729
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| Drug Name |
E7850
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| Synonyms |
Irofulven
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 2 | [1], [2] | |
| Company |
Eisai
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H18O3
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| Canonical SMILES |
CC1=C(C2=C(C3(CC3)C(C(=O)C2=C1)(C)O)C)CO
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| InChI |
1S/C15H18O3/c1-8-6-10-12(11(8)7-16)9(2)15(4-5-15)14(3,18)13(10)17/h6,16,18H,4-5,7H2,1-3H3/t14-/m0/s1
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| InChIKey |
NICJCIQSJJKZAH-AWEZNQCLSA-N
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| CAS Number |
CAS 158440-71-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:135002
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Serine/threonine-protein kinase Chk2 (RAD53) | Target Info | Modulator | [3] |
| KEGG Pathway | Cell cycle | |||
| p53 signaling pathway | ||||
| HTLV-I infection | ||||
| Pathway Interaction Database | ATM pathway | |||
| FOXM1 transcription factor network | ||||
| p53 pathway | ||||
| PLK3 signaling events | ||||
| Reactome | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | |||
| G2/M DNA damage checkpoint | ||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | ||||
| WikiPathways | DNA Damage Response | |||
| ATM Signaling Pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Prostate Cancer | ||||
| Integrated Breast Cancer Pathway | ||||
| Integrated Cancer pathway | ||||
| Cell Cycle | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Irofulven induces replication-dependent CHK2 activation related to p53 status. Biochem Pharmacol. 2007 Feb 15;73(4):469-80. | |||
| REF 2 | ATM-dependent CHK2 activation induced by anticancer agent, irofulven. J Biol Chem. 2004 Sep 17;279(38):39584-92. | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1988). | |||
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