Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00EGU
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| Former ID |
DIB006375
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| Drug Name |
PACAP38
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| Synonyms |
H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-OH
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| Indication | Nerve injury [ICD-11: ND56.4; ICD-10: T14.4] | Phase 1 | [1], [2] | |
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Pituitary adenylate cyclase-activating 38 (PACAP-38) | Target Info | Modulator | [3] |
| KEGG Pathway | Insulin secretion | |||
| Reactome | NGF-independant TRKA activation | |||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| NGF signalling via TRKA from the plasma membrane | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2258). | |||
| REF 2 | ClinicalTrials.gov (NCT02542605) To Evaluate the Blockade of CGRP in Preventing PACAP-38 Induced Migraine-like Attacks With AMG 334 in Migraine Patients. | |||
| REF 3 | Pituitary adenylate cyclase-activating polypeptides, PACAP-38 and PACAP-27, regulation of sympathetic neuron catecholamine, and neuropeptide Y expr... Ann N Y Acad Sci. 1996 Dec 26;805:204-16; discussion 217-8. | |||
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