Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00EEL
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| Former ID |
DAP001385
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| Drug Name |
Gaboxadol
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| Synonyms |
Gaboxadolum; Gaboxadolum [Latin]; LU 2030; Gaboxadol [USAN:INN]; Lu 02-030; MK-0928; Gaboxadol (USAN/INN); LU-2-030; Lu-02-030; Isoxazolo(5,4-c)pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, hydrate; 4,5,6,7-Tetrahydroisoxazole(5,4-c)pyridin-3-ol; 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one
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| Drug Type |
Small molecular drug
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| Indication | Insomnia [ICD-11: 7A00-7A0Z] | Approved | [1], [2] | |
| Therapeutic Class |
Hypnotics and Sedatives
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| Company |
Merck & Co
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| Structure |
 |
Download2D MOL |
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| Formula |
C6H8N2O2
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| Canonical SMILES |
C1CNCC2=C1C(=O)NO2
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| InChI |
1S/C6H8N2O2/c9-6-4-1-2-7-3-5(4)10-8-6/h7H,1-3H2,(H,8,9)
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| InChIKey |
ZXRVKCBLGJOCEE-UHFFFAOYSA-N
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| CAS Number |
CAS 64603-91-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
586282, 5651498, 5694188, 7980780, 8152193, 11111836, 11111837, 11113715, 11335386, 11360625, 11364378, 11366940, 11369502, 11371576, 11373822, 11377664, 11461597, 11467000, 11468120, 11485296, 11486650, 11489406, 11490544, 11491987, 11495298, 12015406, 14747760, 15194598, 26751902, 29222582, 47206216, 47211771, 47365059, 47515197, 47588874, 47885286, 47959606, 47959607, 48110332, 48184876, 48259099, 49698969, 49987818, 50104580, 50684001, 57321806, 81065560, 90341079, 103286434, 104121647
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| ChEBI ID |
CHEBI:34373
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor delta (GABRD) | Target Info | Modulator | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4322). | |||
| REF 2 | Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem. J Sleep Res. 2009 Dec;18(4):387-96. | |||
| REF 3 | Gaboxadol--a new awakening in sleep.Curr Opin Pharmacol.2006 Feb;6(1):30-6. | |||
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