Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00DXC
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| Drug Name |
Macrocycle derivative 13
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| Synonyms |
PMID28270010-Compound-Figure21-a
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Cell proliferative disorder [ICD-11: FB86] | Patented | [1] | |
| Company |
CS THERAPEUTICS INC
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H18FN5O3
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| Canonical SMILES |
CC1C2=C(C=CC(=C2)F)OCCOC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C
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| InChI |
1S/C20H18FN5O3/c1-11-14-8-13(21)3-4-16(14)27-5-6-28-20-18(15(9-22)26(2)25-20)12-7-17(29-11)19(23)24-10-12/h3-4,7-8,10-11H,5-6H2,1-2H3,(H2,23,24)
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| InChIKey |
IAURDDBZTWBKOT-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | BDNF/NT-3 growth factors receptor (TrkB) | Target Info | Inhibitor | [1] |
| Target's Patent Info | BDNF/NT-3 growth factors receptor (TrkB) | Target's Patent Info | [1] | |
| KEGG Pathway | MAPK signaling pathway | |||
| Neurotrophin signaling pathway | ||||
| Alcoholism | ||||
| Pathway Interaction Database | SHP2 signaling | |||
| Posttranslational regulation of adherens junction stability and dissassembly | ||||
| Neurotrophic factor-mediated Trk receptor signaling | ||||
| Reactome | NGF-independant TRKA activation | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| BDNF signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. | |||
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