Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00CLM
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| Former ID |
DIB000287
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| Drug Name |
NIP-004
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| Synonyms |
Blood clotting modulator, Nissan; NIP-022; ONO-7746; ONO-7746); Peptidomimetic thrombopoietin agonist (thrombocytopenia), Nissan Chemical; Peptidomimetic thrombopoietin agonist (thrombocytopenia), Nissan Chemical/Ono
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| Indication | Thrombocytopenia [ICD-11: 3B64] | Phase 1 | [1] | |
| Company |
Nissan Chemical Industries Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C18H12Cl2N2O4S2
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| Canonical SMILES |
CC(=NNC(=O)C1=CC=C(S1)C(=O)O)C2=CSC(=C2O)C3=CC(=C(C=C3)Cl)Cl
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| InChI |
1S/C18H12Cl2N2O4S2/c1-8(21-22-17(24)13-4-5-14(28-13)18(25)26)10-7-27-16(15(10)23)9-2-3-11(19)12(20)6-9/h2-7,23H,1H3,(H,22,24)(H,25,26)/b21-8-
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| InChIKey |
JYODIYJKYDDIDN-WNFQYIGGSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thrombopoietin receptor (MPL) | Target Info | Agonist | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Jak-STAT signaling pathway | ||||
| WikiPathways | Platelet Aggregation (Plug Formation) | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027636) | |||
| REF 2 | A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7. | |||
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