Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00CEG
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| Former ID |
DNC000509
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| Drug Name |
D-43787
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| Synonyms |
D-43787; UNII-18SFZ71BQO; 198016-44-3; 18SFZ71BQO; CTK8E8581; DTXSID30173514; ZINC3960990; d43787; 1H-Indole-1-carboxylic acid, 2-(((2S)-2,3-dihydro-2-((((1S)-1-(methoxycarbonyl)-5-(((phenylmethoxy)carbonyl)amino)pentyl)amino)carbonyl)-1H-indol-1-yl)carbonyl)-2,3-dihydro-, 1,1-dimethylethyl ester, (2S)-; RT-012166; FT-0665439; J-012788; (2S)-2-[[(2S)-2,3-Dihydro-2-[[[(1S)-1-(methoxycarbonyl)-5-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]carbonyl]-1H-indol-1-yl]carbonyl]-2,3-dihydro-1H-Indole-1-carboxylic Acid 1,1-Dime
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| Drug Type |
Small molecular drug
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| Indication | Allergy [ICD-11: 4A80-4A85; ICD-10: T78.4; ICD-9: 995.3] | Terminated | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C38H44N4O8
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| Canonical SMILES |
CC(C)(C)OC(=O)N1C(CC2=CC=CC=C21)C(=O)N3C(CC4=CC=CC=C43)C(=O)NC(CCCCNC(=O)OCC5=CC=CC=C5)C(=O)OC
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| InChI |
1S/C38H44N4O8/c1-38(2,3)50-37(47)42-30-20-11-9-17-27(30)23-32(42)34(44)41-29-19-10-8-16-26(29)22-31(41)33(43)40-28(35(45)48-4)18-12-13-21-39-36(46)49-24-25-14-6-5-7-15-25/h5-11,14-17,19-20,28,31-32H,12-13,18,21-24H2,1-4H3,(H,39,46)(H,40,43)/t28-,31-,32-/m0/s1
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| InChIKey |
GKYGBJABPHBINI-MHDHXZMLSA-N
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| CAS Number |
CAS 198016-44-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| SuperDrug ATC ID |
V03AB02
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| SuperDrug CAS ID |
cas=000062679
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium signal-modulating cyclophilin ligand (CAML) | Target Info | Binder | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010545) | |||
| REF 2 | Anti-inflammatory effects of a cyclosporine receptor-binding compound, D-43787. J Pharmacol Exp Ther. 2002 May;301(2):738-46. | |||
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