Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00BCG
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| Former ID |
DAP000023
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| Drug Name |
Goserelin
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| Synonyms |
AstraZeneca (TN); HS-2015; ZD-9393; Zoladex (TN)
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65] | Approved | [1], [2] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
Zeneca Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C59H84N18O14
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| Canonical SMILES |
CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
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| InChI |
1S/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90)/t38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1
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| InChIKey |
BLCLNMBMMGCOAS-URPVMXJPSA-N
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| CAS Number |
CAS 65807-02-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7979432, 12012688, 14841899, 39340846, 46507336, 47206287, 50769325, 53787041, 92308752, 93815084, 99031212, 114155337, 131285775, 135006900, 137240554, 152134072, 162224781, 162263907, 170474033, 176484181, 178100715, 179150873, 179150874, 187072141, 210274923, 210280559, 223860389, 226399792, 248160083, 251915680, 251917030, 252358945
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| ChEBI ID |
CHEBI:5523
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| ADReCS Drug ID | BADD_D01038 ; BADD_D01039 | |||
| SuperDrug ATC ID |
L02AE03
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| SuperDrug CAS ID |
cas=065807025
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Leutinizing-hormone-releasing hormone (GNRH1) | Target Info | Activator | [3] |
| KEGG Pathway | GnRH signaling pathway | |||
| Pathway Interaction Database | Nongenotropic Androgen signaling | |||
| Reactome | Hormone ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3879). | |||
| REF 2 | Luteinizing hormone-releasing hormone agonists in premenopausal hormone receptor-positive breast cancer. Clin Breast Cancer. 2007 Feb;7(6):455-64. | |||
| REF 3 | Long-term effectiveness of adjuvant goserelin in premenopausal women with early breast cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):341-9. | |||
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