Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00AJI
|
|||
| Former ID |
DIB000249
|
|||
| Drug Name |
PF-4480682
|
|||
| Indication | Neuropathic pain [ICD-11: 8E43.0] | Discontinued in Phase 2 | [1] | |
| Company |
Pfizer Inc
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-2 (GABRA2) | Target Info | Modulator | [2] |
| GABA(A) receptor delta (GABRD) | Target Info | Modulator | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025530) | |||
| REF 2 | WO patent application no. 2014,1515,17, Methods of improving microvascular integrity. | |||
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