Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00ABO
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| Former ID |
DIB013009
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| Drug Name |
KW-2449
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| Synonyms |
Tumor antigen-specific mAb (cancer), Kyowa; Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kirin; Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kogyo
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| Drug Type |
Small molecular drug
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| Indication | Acute myeloid leukaemia [ICD-11: 2A60] | Phase 1 | [1], [2] | |
| Company |
Kyowa Hakko Kogyo Co Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H20N4O
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| Canonical SMILES |
C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43
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| InChI |
1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+
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| InChIKey |
YYLKKYCXAOBSRM-JXMROGBWSA-N
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| CAS Number |
CAS 841258-76-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16524833, 23572482, 42506629, 78872837, 104253487, 124757616, 125164420, 135308373, 136340303, 136348733, 136367588, 136944791, 136959520, 144116115, 152258183, 160647019, 162011874, 162037789, 162202554, 163908008, 164193999, 172919160, 174525716, 178102318, 186014843, 223705272, 224065372, 227791140, 227791143, 252215657
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| ChEBI ID |
CHEBI:91441
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5691). | |||
| REF 2 | KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood. 2009 Aug 20;114(8):1607-17. | |||
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