Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y3OO
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| Former ID |
DNC005258
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| Drug Name |
NU-7432
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| Synonyms |
NU-7441
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C25H19NO3S
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| Canonical SMILES |
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56
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| InChI |
1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
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| InChIKey |
JAMULYFATHSZJM-UHFFFAOYSA-N
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| CAS Number |
CAS 503468-95-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16417480, 23490675, 44368733, 57376460, 74928374, 99007707, 103456957, 104043621, 125317239, 134342463, 135686170, 135686171, 135686192, 135686193, 135697740, 136340351, 136349532, 136367663, 136920404, 137275878, 141654511, 144116112, 152258305, 152344410, 160647144, 162011555, 162038133, 162202628, 163125204, 164763745, 172818890, 172919157, 174561037, 177749067, 180371645, 186014817, 204362726, 208265575, 223705212, 226902816, 241376599, 242060129, 249274457, 249565690, 252157476, 252160169, 252215655, 252543368
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| ChEBI ID |
CHEBI:91361
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA-dependent protein kinase catalytic (PRKDC) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Non-homologous end-joining | |||
| Cell cycle | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | |||
| Coregulation of Androgen receptor activity | ||||
| Class I PI3K signaling events mediated by Akt | ||||
| BARD1 signaling events | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | |||
| WikiPathways | DNA Damage Response | |||
| Non-homologous end joining | ||||
| FAS pathway and Stress induction of HSP regulation | ||||
| Cytosolic sensors of pathogen-associated DNA | ||||
| Retinoblastoma (RB) in Cancer | ||||
| Prostate Cancer | ||||
| Double-Strand Break Repair | ||||
| Cell Cycle | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8010). | |||
| REF 2 | Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. | |||
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