Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X5LN
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| Former ID |
DNC007270
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| Drug Name |
7,8,3',4'-tetrahydroxyflavone
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| Synonyms |
7,8,3',4'-tetrahydroxyflavone; 3440-24-2; 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4-one; 3',4',7,8-Tetrahydroxyflavone; CHEMBL222541; ARYCMKPCDNHQCL-UHFFFAOYSA-N; ST059620; 2-(3,4-dihydroxyphenyl)-7,8-dihydroxychromen-4-one; AC1LEMTC; AC1Q6AJ1; SCHEMBL35318; CTK4H2335; ZINC57844; DTXSID20350973; 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4h-chromen-4-on; CHEBI:125596; 7,8,3'',4''-tetrahydroxyflavone; BDBM50157547; AKOS024283046; ACM3440242; MCULE-5496936655; ZB002260; DB-048618; FT-0614178; C-57754
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H10O6
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| Canonical SMILES |
C1=CC(=C(C=C1C2=CC(=O)C3=C(O2)C(=C(C=C3)O)O)O)O
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| InChI |
1S/C15H10O6/c16-9-3-1-7(5-12(9)19)13-6-11(18)8-2-4-10(17)14(20)15(8)21-13/h1-6,16-17,19-20H
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| InChIKey |
ARYCMKPCDNHQCL-UHFFFAOYSA-N
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| CAS Number |
CAS 3440-24-2
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:125596
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | TERT messenger RNA (TERT mRNA) | Target Info | Inhibitor | [1] |
| KEGG Pathway | HTLV-I infection | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
| Regulation of Telomerase | ||||
| IL2 signaling events mediated by PI3K | ||||
| Regulation of nuclear beta catenin signaling and target gene transcription | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Formation of the beta-catenin:TCF transactivating complex | |||
| WikiPathways | TGF beta Signaling Pathway | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| Telomere Maintenance | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Catecholic flavonoids acting as telomerase inhibitors. J Med Chem. 2004 Dec 16;47(26):6466-75. | |||
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