Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q4SD
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| Former ID |
DAP000085
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| Drug Name |
Eplerenone
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| Synonyms |
Epoxymexrenone; Inspra; Selara; CGP-30083; Inspra (TN); SC-66110; Eplerenone (JAN/USAN/INN); Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone; 7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
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| Drug Type |
Small molecular drug
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| Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Approved | [1], [2] | |
| Therapeutic Class |
Antihypertensive Agents
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| Company |
Pfizer Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C24H30O6
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| Canonical SMILES |
CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC
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| InChI |
1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
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| InChIKey |
JUKPWJGBANNWMW-VWBFHTRKSA-N
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| CAS Number |
CAS 107724-20-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
582902, 7848178, 7978615, 10944293, 12015198, 14879938, 14904453, 26754514, 36544725, 46509053, 49830291, 53787272, 56352903, 57404541, 71826056, 74735937, 91748944, 92720250, 103752013, 104152661, 104253325, 104630900, 124757444, 125164248, 126620102, 126655086, 127327776, 127327777, 127327778, 135107050, 135650235, 135692237, 136077139, 137101310, 142093240, 144205299, 152101726, 160870987, 162037710, 162248542, 164786776, 170465283, 175267681, 175423520, 176484681, 179149556, 184545427, 187072493, 196109783, 210279392
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| ChEBI ID |
CHEBI:31547
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| ADReCS Drug ID | BADD_D00786 | |||
| SuperDrug ATC ID |
C03DA04
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| SuperDrug CAS ID |
cas=107724209
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Mineralocorticoid receptor (MR) | Target Info | Modulator | [3] |
| KEGG Pathway | Aldosterone-regulated sodium reabsorption | |||
| Pathwhiz Pathway | Kidney Function | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2876). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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