Drug Information

Drug General Information

Drug ID

D0LQ3L

Drug Name

GSK2982772

Synonyms

LYPAFUINURXJSG-AWEZNQCLSA-N; 1622848-92-3; UNII-T5W3M0VO9B; T5W3M0VO9B; GSK-2982772; (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-3-carboxamide; GTPL9554; SCHEMBL15956219; MolPort-044-830-634; s8484; AKOS030528033; compound 5 [PMID: 28151659]; ACN-041458; CS-6899; GSK 2982772; AS-35128; AC-29894; HY-101760; J3.650.802G; 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide; 3-Benzyl-N-[(3s)-5-Methyl-4-Oxo-2,3,4,5-Tetrahydr

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Indication

Plaque psoriasis [ICD-11: EA90.0; ICD-10: L40.0]

Phase 2

[1]

Psoriasis vulgaris [ICD-11: EA90; ICD-9: 696]

Phase 1

[2]

Rheumatoid arthritis [ICD-11: FA20]

Phase 1

[2]

Ulcerative colitis [ICD-11: DD71; ICD-9: 556]

Phase 1

[2]

Company

GlaxoSmithKline Research Triangle Park, NC

Structure

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2D MOL

3D MOL

Formula

C20H19N5O3

Canonical SMILES

CN1C2=CC=CC=C2OCC(C1=O)NC(=O)C3=NNC(=N3)CC4=CC=CC=C4

InChI

1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23-24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14-/m0/s1

InChIKey

LYPAFUINURXJSG-AWEZNQCLSA-N

CAS Number

CAS 1622848-92-3

PubChem Compound ID

77108121

Target and Pathway

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Target(s)

Receptor-interacting protein 1 (RIPK1)

Target Info

Inhibitor

[1], [2]

References

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REF 1

Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)

REF 2

Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)

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