Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0I5TV
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| Former ID |
DIB019700
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| Drug Name |
dATPalphaS
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| Synonyms |
Datpalphas; [[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate; 2'-Deoxyadenosine 5'-O-(1-thiotriphosphate); alpha-Thio-datp; Sp-Datp alpha S; Sp-dATP-.alpha.-S; AC1L51OG; SCHEMBL222923; GTPL1715; CHEMBL2390988; alpha-Thiodeoxyadenosine triphosphate; Deoxyadenosine 5'-(alpha-thio)triphosphate; 2'-deoxyadenosine-5'-O-(1-thiotriphosphate); (Sp-)2'- Deoxyadenosine- 5'- O- (.alpha.-thiotriphosphate); Adenosine, 2'-deoxy-, 5'-P''-ester with thiotriphosphoric ac
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C10H16N5O11P3S
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| Canonical SMILES |
C1C(C(OC1N2C=NC3=C(N=CN=C32)N)COP(=S)(O)OP(=O)(O)OP(=O)(O)O)O
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| InChI |
1S/C10H16N5O11P3S/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(24-7)2-23-29(22,30)26-28(20,21)25-27(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H,22,30)(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+,29?/m0/s1
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| InChIKey |
CCPIKNHZOWQALM-DLQJRSQOSA-N
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| CAS Number |
CAS 64145-28-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
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| Target(s) | P2Y purinoceptor 1 (P2RY1) | Target Info | Agonist | [2] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Platelet activation | ||||
| Reactome | G alpha (q) signalling events | |||
| P2Y receptors | ||||
| ADP signalling through P2Y purinoceptor 1 | ||||
| WikiPathways | Nucleotide GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Signal amplification | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1715). | |||
| REF 2 | An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor. Br J Pharmacol. 1997 May;121(2):338-44. | |||
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