Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0I0EG
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| Former ID |
DAP000589
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| Drug Name |
Captopril
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| Synonyms |
Acediur; Aceplus; Acepress; Acepril; Alopresin; Apopril; Asisten; Capoten; Captolane; Captoprilum; Captopryl; Captoril; Captril; Cesplon; Dilabar; Garranil; Hipertil; Hypertil; Isopresol; Lopirin; Lopril; MCO; Tenosbon; Tensiomin; Tensobon; Tensoprel; Lopirin [Switzerland]; C 4042; SA 333; SQ 14225; X8Z; Apopril (TN); Capoten (TN); Captoprilum [INN-Latin]; Garranil (discontinued); L-Captopril; SQ 14,225; SQ-14225; SQ-14534; SQ-14,225; SQ-14,534; Captopril (JP15/USP/INN); Captopril [USAN:INN:BAN:JAN]; D-3-Mercapto-2-methylpropionylproline; D-2-Methyl-3-mercaptopropanoyl-L-proline; D-3-Mercapto-2-methylpropanoyl-L-proline; [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline; N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline;(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline; (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid; (S)-1-(3-Mercapto-2-methyl-1-oxo-propyl)-L-proline; (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline; 1-((2S)-3-Mercapto-2-methylpropionyl)-L-proline; 1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline; 1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S,S); 1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline; 3-Mercapto-2-methylpropionyl-proline
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1], [2] | |
| Therapeutic Class |
Antihypertensive Agents
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| Company |
Bristol-Myers Squibb
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| Structure |
 |
Download2D MOL |
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| Formula |
C9H15NO3S
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| Canonical SMILES |
CC(CS)C(=O)N1CCCC1C(=O)O
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| InChI |
1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
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| InChIKey |
FAKRSMQSSFJEIM-RQJHMYQMSA-N
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| CAS Number |
CAS 62571-86-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
823180, 855925, 3154070, 7847317, 7978852, 8149632, 8178487, 10321204, 11110941, 11335383, 11360622, 11363582, 11366144, 11368706, 11372295, 11374460, 11376868, 11461594, 11484758, 11489027, 11491203, 11492626, 11494502, 11533495, 12013747, 14797867, 15195876, 17404865, 22391411, 24278149, 24893111, 26612024, 26679590, 26747043, 26747044, 26751563, 26758381, 34709396, 46392259, 46487953, 46506879, 47365058, 47440133, 47515193, 47515194, 47515195, 47736347, 47736348, 47959603, 49698307
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| ChEBI ID |
CHEBI:3380
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| ADReCS Drug ID | BADD_D00354 | |||
| SuperDrug ATC ID |
C09AA01
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| SuperDrug CAS ID |
cas=062571862
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin-converting enzyme (ACE) | Target Info | Inhibitor | [3] |
| KEGG Pathway | Renin-angiotensin system | |||
| Chagas disease (American trypanosomiasis) | ||||
| Hypertrophic cardiomyopathy (HCM) | ||||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5158). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074322. | |||
| REF 3 | Using ACE inhibitors appropriately. Am Fam Physician. 2002 Aug 1;66(3):461-8. | |||
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