Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H9SX
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| Former ID |
DIB014929
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| Drug Name |
Daporinad
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| Synonyms |
APO-866; FK-866; WK-175
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | leukaemia [ICD-11: 2A60-2B33; ICD-9: 208.9] | Phase 2 | [1], [2] | |
| Company |
Astellas Pharma GmbH
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| Structure |
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Download2D MOL |
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| Formula |
C24H29N3O2
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| Canonical SMILES |
C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3
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| InChI |
1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
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| InChIKey |
KPBNHDGDUADAGP-VAWYXSNFSA-N
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| CAS Number |
CAS 658084-64-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11538981, 14780790, 17192219, 43526910, 46394178, 46394209, 53790372, 75004561, 103699847, 104503566, 114781462, 131341969, 135267025, 135290575, 135351996, 135697735, 137236278, 141035236, 144115979, 152133995, 152159605, 152344381, 163621115, 163685700, 163686454, 163981454, 164194112, 172919044, 175426320, 175607620, 177748701, 186014805, 187071987, 198977556, 204372575, 221121841, 221121846, 223366078, 249814512, 251910568, 252160019, 252215425, 252471670
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| ChEBI ID |
CHEBI:94671
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nicotinamide phosphoribosyltransferase (NAMPT) | Target Info | Inhibitor | [2] |
| BioCyc | NAD salvage | |||
| KEGG Pathway | Nicotinate and nicotinamide metabolism | |||
| Metabolic pathways | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| IL1 Signaling Pathway | ||||
| TCR Signaling Pathway | ||||
| Pathwhiz Pathway | Nicotinate and Nicotinamide Metabolism | |||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||
| WikiPathways | Adipogenesis | |||
| Metabolism of water-soluble vitamins and cofactors | ||||
| Circadian Clock | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7745). | |||
| REF 2 | Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804. | |||
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