Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H0AU
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| Former ID |
DIB008176
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| Drug Name |
VER-155008
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| Synonyms |
Heat shock protein 70 inhibitor (cancer), Vernalis; Hsp 70 inhibitor (cancer), Vernalis
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Preclinical | [1] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [2] | ||
| Company |
Vernalis plc
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| Structure |
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Download2D MOL |
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| Formula |
C25H23Cl2N7O4
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| Canonical SMILES |
C1=CC(=CC=C1COCC2C(C(C(O2)N3C4=NC=NC(=C4N=C3NCC5=CC(=C(C=C5)Cl)Cl)N)O)O)C#N
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| InChI |
1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1
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| InChIKey |
ZXGGCBQORXDVTE-UMCMBGNQSA-N
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| CAS Number |
CAS 1134156-31-2
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:95010
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. | |||
| REF 2 | The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. | |||
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