Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0EG1I
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| Former ID |
DNAP001690
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| Drug Name |
Tofacitinib
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| Synonyms |
Tasocitinib; 477600-75-2; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; CP-690550; CP 690550; racemic-tofacitinib; 1259404-17-5; tofacitinibum; CP-690,550; UNII-87LA6FU830; 3-((3R,4R)-rel-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile; Tofacitinib (CP-690550,Tasocitinib); CHEMBL221959; CHEBI:71200; Xeljanz (TN)
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| Drug Type |
Small molecular drug
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| Indication | Rheumatoid arthritis [ICD-11: FA20] | Approved | [1], [2], [3] | |
| Company |
Pfizer
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| Structure |
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Download2D MOL |
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| Formula |
C16H20N6O
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| Canonical SMILES |
CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N
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| InChI |
1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
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| InChIKey |
UJLAWZDWDVHWOW-YPMHNXCESA-N
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| CAS Number |
CAS 477600-75-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14898931, 16573063, 24203044, 50100095, 56468341, 56479518, 80408829, 93578178, 93578180, 99005545, 99436938, 99444654, 103506979, 104076339, 109693014, 118049771, 124757868, 124939204, 124939205, 125164719, 126617354, 126636329, 131541360, 134344290, 135253188, 135626691, 135697694, 135723912, 136367982, 137055230, 142909486, 143498234, 144115851, 152159600, 152239919, 152258788, 152344045, 160646103, 160647639, 160819105, 160969237, 162011739, 162133672, 162193956, 162766622, 164043529, 164194011, 164783370, 170482324, 170482440
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| ChEBI ID |
CHEBI:71200
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| ADReCS Drug ID | BADD_D02236 ; BADD_D02237 | |||
| SuperDrug ATC ID |
L04AA29
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5677). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | ClinicalTrials.gov (NCT02157012) Evaluation of the Condition of Rheumatoid Arthritis After Treatment. U.S. National Institutes of Health. | |||
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