Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D6MH
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| Former ID |
DIB019981
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| Drug Name |
GW-2580
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| Synonyms |
GW2580; cFMS receptor tyrosine kinase inhibitor; GW632580X
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C20H22N4O3
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| Canonical SMILES |
COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC
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| InChI |
1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
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| InChIKey |
MYQAUKPBNJWPIE-UHFFFAOYSA-N
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| CAS Number |
CAS 870483-87-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16720475, 23726246, 26758710, 50100101, 53800773, 79254755, 99302679, 103567703, 103905623, 124349955, 134352694, 134353091, 137355269, 143472530, 162012043, 163123671, 163688133, 163779908, 170484718, 172087029, 172650488, 172652491, 175607408, 176485314, 178102312, 180372393, 186006545, 189158925, 198950783, 204377784, 208264983, 208265629, 215778467, 223573728, 223843997, 230266506, 242059754, 247419869, 252215520, 252451474, 252553667, 252615797
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CSF1R messenger RNA (CSF1R mRNA) | Target Info | Inhibitor | [1] |
| NetPath Pathway | TCR Signaling Pathway | |||
| Notch Signaling Pathway | ||||
| Pathway Interaction Database | Signaling events mediated by PTP1B | |||
| Signaling events mediated by TCPTP | ||||
| Integrins in angiogenesis | ||||
| C-MYB transcription factor network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83. | |||
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