Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08MHM
|
|||
| Former ID |
DND000007
|
|||
| Drug Name |
PF-3758309
|
|||
| Synonyms |
PF-309
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
| Company |
Pfizer
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C25H30N8OS
|
|||
| Canonical SMILES |
CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)NC(CN(C)C)C5=CC=CC=C5)SC=C2
|
|||
| InChI |
1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1
|
|||
| InChIKey |
AYCPARAPKDAOEN-LJQANCHMSA-N
|
|||
| CAS Number |
CAS 898044-15-0
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:93751
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | PAK-4 protein kinase (PAK4) | Target Info | Inhibitor | [1] |
| KEGG Pathway | ErbB signaling pathway | |||
| Ras signaling pathway | ||||
| Axon guidance | ||||
| Focal adhesion | ||||
| T cell receptor signaling pathway | ||||
| Regulation of actin cytoskeleton | ||||
| MicroRNAs in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Cytoskeletal regulation by Rho GTPase | |||
| Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| Pathway Interaction Database | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | |||
| CDC42 signaling events | ||||
| FGF signaling pathway | ||||
| WikiPathways | ErbB Signaling Pathway | |||
| Regulation of Actin Cytoskeleton | ||||
| Focal Adhesion | ||||
| Integrin-mediated Cell Adhesion | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.