Drug Information
Drug General Information | Top | |||
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Drug ID |
D07RPV
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Former ID |
DNC008843
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Drug Name |
HALOPEMIDE
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Synonyms |
Halopemide; 59831-65-1; UNII-65Q28TV0ZY; R 34,301; MLS003171133; 65Q28TV0ZY; CHEMBL245621; R-34301; N-(2-(4-(5-Chloro-2-oxo-1-benzimidazolinyl)piperidino)ethyl)-p-fluorobenzamide; Halopemida; Halopemidum; Halopemide [USAN:INN]; Halopemidum [INN-Latin]; Halopemida [INN-Spanish]; C21H22ClFN4O2; N-[2-[4-(5-Chloro-2-oxo-1-benzimidazolinyl)piperidino]ethyl]-p-fluorobenzamide; Halopemide, 8; NSC 354856; Halopemide (USAN/INN); AC1L23CG; R 34301; MLS006012046; cid_65490; SCHEMBL121267; Halopemide, > CTK8G0128; AOB5520
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C21H22ClFN4O2
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Canonical SMILES |
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCNC(=O)C4=CC=C(C=C4)F
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InChI |
1S/C21H22ClFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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InChIKey |
NBHPRWLFLUBAIE-UHFFFAOYSA-N
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CAS Number |
CAS 59831-65-1
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Phospholipase D (PLD) | Target Info | Inhibitor | [1] |
Phospholipase D1 (PLD1) | Target Info | Inhibitor | [1] | |
BioCyc | Phospholipases | |||
KEGG Pathway | Glycerophospholipid metabolism | |||
Ether lipid metabolism | ||||
Metabolic pathways | ||||
Ras signaling pathway | ||||
cAMP signaling pathway | ||||
Sphingolipid signaling pathway | ||||
Endocytosis | ||||
Fc gamma R-mediated phagocytosis | ||||
Glutamatergic synapse | ||||
GnRH signaling pathway | ||||
Pathways in cancer | ||||
Pancreatic cancer | ||||
Choline metabolism in cancer | ||||
Panther Pathway | Angiogenesis | |||
Ras Pathway | ||||
Pathway Interaction Database | RhoA signaling pathway | |||
Arf6 trafficking events | ||||
CDC42 signaling events | ||||
Arf6 downstream pathway | ||||
mTOR signaling pathway | ||||
ErbB1 downstream signaling | ||||
IL8- and CXCR1-mediated signaling events | ||||
Alpha-synuclein signaling | ||||
Reactome | Role of phospholipids in phagocytosis | |||
WikiPathways | EGF/EGFR Signaling Pathway | |||
TSH signaling pathway |
References | Top | |||
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REF 1 | Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17. |
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