Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01SHZ
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| Former ID |
DNCL002606
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| Drug Name |
Rucaparib
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| Synonyms |
RUCAPARIB; 283173-50-2; Rubraca; AG-14447; UNII-8237F3U7EH; 8237F3U7EH; AK317822; 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one; 8-FLUORO-2-(4-((METHYLAMINO)METHYL)PHENYL)-4,5-DIHYDRO-1H-AZEPINO[5,4,3-CD]INDOL-6(3H)-ONE; 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-; 8-fluoro-2-(4-methylaminomethyl-phenyl)-1,3,4,5-tetrahydro-azepino[5,4,3-cd]indol-6-one
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| Drug Type |
Small molecular drug
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| Indication | Ovarian cancer [ICD-11: 2C73; ICD-10: C56] | Approved | [1] | |
| Company |
Clovis Oncology
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H18FN3O
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| Canonical SMILES |
CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2
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| InChI |
1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)
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| InChIKey |
HMABYWSNWIZPAG-UHFFFAOYSA-N
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| CAS Number |
CAS 283173-50-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16463842, 24207084, 76934109, 103769588, 103905261, 121278129, 128080164, 135626799, 137263927, 137276017, 142270192, 152037846, 162108736, 162829534, 164208495, 170474818, 172918029, 174006354, 177748908, 185992962, 194944026, 198980201, 210274713, 210280347, 223366069, 223471430, 223804825, 227116711, 249625884
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| ChEBI ID |
CHEBI:94311
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| ADReCS Drug ID | BADD_D02510 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase (PARP) | Target Info | Modulator | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. | |||
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