Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00OVU
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| Former ID |
DNC010908
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| Drug Name |
Suvorexant
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| Synonyms |
Suvorexant; 1030377-33-3; MK-4305; BELSOMRA; MK 4305; MK4305; UNII-081L192FO9; Suvorexant (MK-4305); [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone; (R)-(4-(5-Chlorobenzo[d]oxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone; CHEMBL1083659; CHEBI:82698; 081L192FO9; C23H23ClN6O2; ((7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
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| Drug Type |
Small molecular drug
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| Indication | Insomnia [ICD-11: 7A00-7A0Z] | Approved | [1], [2], [3] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H23ClN6O2
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| Canonical SMILES |
CC1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl
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| InChI |
1S/C23H23ClN6O2/c1-15-3-5-20(30-25-8-9-26-30)18(13-15)22(31)29-12-11-28(10-7-16(29)2)23-27-19-14-17(24)4-6-21(19)32-23/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3/t16-/m1/s1
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| InChIKey |
JYTNQNCOQXFQPK-MRXNPFEDSA-N
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| CAS Number |
CAS 1030377-33-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
56264110, 57493879, 99431637, 103755866, 104153062, 134348113, 135267387, 135650615, 136946578, 138669889, 141618580, 152258025, 152258268, 160647104, 163312227, 164044652, 171061162, 175266695, 176245483, 184816450, 198993974, 215784570, 223377940, 223447420, 223620167, 223704064, 225372552, 227781057, 248624194, 249822123, 250214353, 251963163, 252062692, 252211821, 252215820, 252442778, 252473529
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| ChEBI ID |
CHEBI:82698
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| ADReCS Drug ID | BADD_D02103 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Orexin receptor type 2 (HCRTR2) | Target Info | Modulator | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2890). | |||
| REF 2 | 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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