Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D0Z0KH | ||||||||||
| Drug Name | Azole | ||||||||||
| Synonyms | PYRROLE; 1H-Pyrrole; 109-97-7; Divinylenimine; Imidole; Pyrrol; Monopyrrole; Divinyleneimine; 1-Aza-2,4-cyclopentadiene; polypyrrole; UNII-86S1ZD6L2C; NSC 62777; FEMA No. 3386; PYROLLE; CCRIS 2933; HSDB 119; CHEBI:19203; 1H-Pyrrole, homopolymer; EINECS 203-724-7; 1H-Pyrrole, potassium salt; AI3-18817; 86S1ZD6L2C; KAESVJOAVNADME-UHFFFAOYSA-N; MFCD00005216; Pyrrole, 99%, extra pure; 30604-81-0; Pyrrhol; 1-H-pyrrole; Pyrrole, Extra Pure; PubChem16729; 16199-06-7; DSSTox_CID_1910; WLN: T5MJ; Epitope ID:136031; AC1L1Q3I; AC1Q4W0S | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | Fungal Delta(7)-sterol 5(6)-desaturase (ERG3) | Target Info | |||||||||
| Gene Name | ERG3 | ||||||||||
| Uniprot ID | A0A1L2BH72_CANPA | ||||||||||
| Species | Candida parapsilosis | ||||||||||
| Reference Sequence |
MDIVLEVCDYYLFDRLYAAALPKGGKVDQFIQNSPVFQQVSSKISQFLPSSSCSGCSDTV DNALFGNTTASSTFSNALNFQFNATSVNVANLPSYLWSKVMSLQNKSEIYRLKPTFLPAG DYFSSSILARSNLLRESLTILVITTIFGWLLYLIVAYLSYVFVFDRRIFNHPRYLKNQMW LEIERAMTAIPVMVALTNPFFLLELKGFSRLYFDINECTGGWKFVFLQIPMFILFTDCLI YCIHRWLHWPSVYKRLHKPHHKWIVCTPFASHAFHPVDGWAQSLPYHLYPLLFPLHKVLY LGLFTFVNFWTVMIHDGNYMSNDPVVNGTACHTVHHLYFNYNYGQFTTLWDRIGRSYRRP DDSFFIKETTAEKEKQEWKKQVTQMEEIRNELEGKVDDREYAEES [Candida parap silosis] |
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| Targeted Disease | Candida infection | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Impact of ERG3 mutations and expression of ergosterol genes controlled by UPC2 and NDT80 in Candida parapsilosis azole resistance.Clin Microbiol Infect.2017 Aug;23(8):575. | ||||||||||
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