Resistance mutation info of drug
Drug General Information | |||||||||||
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Drug ID | D0W9MM | ||||||||||
Drug Name | Vinblastine | ||||||||||
Synonyms | Nincaluicolflastine; Rozevin; VLB; Vinblastin; Vinblastina; Vinblastinum; Vincaleucoblastin; Vincaleucoblastine; Vincaleukoblastine; Vincoblastine; Vinblastina [DCIT]; VR-8; Vinblastina (TN); Vinblastine (INN); Vinblastine [INN:BAN]; Vinblastinum [INN-Latin]; NDC 0002-1452-01; (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE; (2xi,3beta,4'beta,19xi)-vincaleukoblastine; 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid | ||||||||||
Drug Type | Small molecular drug | ||||||||||
Therapeutic Class | Anticancer Agents | ||||||||||
Company | Eli Lilly And Co | ||||||||||
Structure | |||||||||||
Drug Resistance Mutations | |||||||||||
Target Name | Cellular tumor antigen p53 (TP53) | Target Info | |||||||||
Gene Name | TP53 | ||||||||||
Uniprot ID | P53_HUMAN | ||||||||||
Species | Homo sapiens | ||||||||||
Reference Sequence |
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD [Homo sapiens] |
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Targeted Disease | Leukemia | ||||||||||
Drug Resistance Mutations |
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References | |||||||||||
REF 1 | A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line. Oncogene. 2000 Oct 19;19(44):5098-105. |
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