| Drug General Information |
| Drug ID |
D0OG4A
|
| Drug Name |
Kirromycin |
|
| Drug Type |
Small molecular drug |
| Structure |
|
| Drug Resistance Mutations |
| Target Name |
Bacterial Elongation factor Tu (EF-Tu) |
Target Info |
| Gene Name |
EF-Tu |
| Uniprot ID |
EFTU_PEPD6 |
| Species |
Peptoclostridium difficile |
| Reference Sequence |
MAKAKYERTKPHVNIGTIGHVDHGKTTLTAAITKTLYDRYQLGEAVDFANIDKAPEERER
GITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSATDGPMPQTREH
ILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLTEYDFPGDDTPIVRGSALMAL
EDPKSEWGDKIVELFEQIDEYIPAPERDTDKPFLMPVEDVFSITGRGTVATGRVERGVLK
VQDEVELVGLTEAPRKVVVTGVEMFRKLLDQAQAGDNIGALLRGVQRNEIERGQVLAKTG
SVKAHTKFTAEVYVLKKEEGGRHTPFFDGYRPQFYFRTTDVTGACKLPEGIEMVMPGDNV
TMEVDLINSIVVEEGLRFSIREGGRTVASGVVATIIE [Peptoclostridium diff
icile]
|
| Drug Resistance Mutations |
| Mutation info |
Missense: A376S |
[1] |
|
| Mutation info |
Missense: A376V |
[1] |
|
| Mutation info |
Missense: E379K |
[1] |
|
| Mutation info |
Missense: G317D |
[1] |
|
| Mutation info |
Missense: L121Q |
[1] |
|
| Mutation info |
Missense: Q125E |
[1] |
|
| Mutation info |
Missense: Q125K |
[1] |
|
| Mutation info |
Missense: Q125R |
[1] |
|
| Mutation info |
Missense: Y161C |
[1] |
|
| Mutation info |
Missense: Y161D |
[1] |
|
| Mutation info |
Missense: Y161N |
[1] |
|
| References |
| REF 1 |
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
|
