Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D0I6GC | ||||||||||
| Drug Name | NOGGIN | ||||||||||
| Drug Resistance Mutations | |||||||||||
| Target Name | Growth differentiation factor-5 (GDF5) | Target Info | |||||||||
| Gene Name | GDF5 | ||||||||||
| Uniprot ID | GDF5_HUMAN | ||||||||||
| Species | Homo sapiens | ||||||||||
| Reference Sequence |
MRLPKLLTFLLWYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPLARNVFRP GGHSYGGGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATAR TVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTL SDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELR ILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLF RNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKA RSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIA PLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFID SANNVVYKQYEDMVVESCGCR [Homo sapiens] |
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| Targeted Disease | Multiple synostosis syndrome | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.PLoS Genet.2009 Nov;5(11):e1000747. | ||||||||||
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