Resistance mutation info of drug
Drug General Information | |||||||||||
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Drug ID | D0EV6T | ||||||||||
Drug Name | Tipranavir | ||||||||||
Synonyms | Aptivus; TPV; PNU 140690; U 140690; Aptivus (Boehringer Ingelheim); Aptivus (TN); Aptivus(TM); PNU-140690; PNU-140690E; Tipranavir (INN); U-140690; N-[3-[(1R)-1-[(2R)-6-hydroxy-4-oxo-2-phenethyl-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide; N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE | ||||||||||
Drug Type | Small molecular drug | ||||||||||
Therapeutic Class | Anti-HIV Agents | ||||||||||
Company | Boehriger Ingelheim | ||||||||||
Structure | |||||||||||
Drug Resistance Mutations | |||||||||||
Target Name | HIV Protease | Target Info | |||||||||
Uniprot ID | POL_HV1B1(501-599) | ||||||||||
Species | Human immunodeficiency virus type 1 (HIV-1) | ||||||||||
Reference Sequence |
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF [Human immunodeficie ncy virus type 1 (HIV-1)] |
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Targeted Disease | HIV infection | ||||||||||
Drug Resistance Mutations |
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References | |||||||||||
REF 1 | Prediction of drug-resistance in HIV-1 subtype C based on protease sequences from ART naive and first-line treatment failures in North India using genotypic and docking analysis. Antiviral Res. 2011 Nov;92(2):213-8. |
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