Resistance mutation info of drug

Drug General Information
Drug ID D0D5FR
Drug Name Organosphosphates
Drug Resistance Mutations
Target Name Culex pipiens Acetylcholinestrerase (Ace1) Target Info
Gene Name ace1
Uniprot ID Q86CZ4_TETUR
Species Tetranychus urticae
Reference Sequence MVPMFNHNINHFNNVIVTTLTHHQYTNSRCNSNNNVIKRITNSILKSVTVFTVKTLWNHL
LVPIVVILLFQSSANVFSSALPHSEINSFHADGPSSSSSFNSEHHHHHHHNDPLVVLTKK
GYVRGRSVVSPTGKPVDAFLGIRYAKPPTGKFRFRHPKPIDSWQGIFNATSFSGACYQVN
DTFFGNFMGATEWNPNVPLDEDCLSVNIWVPRPRPKSAAVLLWIYGGSFWSGSSSLDFYD
GSVLAGEESIIFVSINYRVASLGFIFFDTSDAPGNAGLFDQLMAMEWIRENIAAFGGNPA
NITIFGESAGAVSAALHLLSPLSRNVFSQAILQSGSATCPWAISDRKKAYQRSLALAQAV
GCGSTSTRSVHAIIECMQSIPASELVAQEETTTGVVEFAFIPIVDGSFLDEDPEVSLRTK
NFKHTPILTGSNRDEGTYFLVYHSPHIFNLSEGIYISRSEFQSLIRIIYPHLSPLAQEAV
IQEYTHWINPDDQIENREATDKFVGDYHFTCPVNEMSYRYALYGNDVWTYHFTHRSSKSF
WPSWMGVIHGEEIKFVLGEPLDPVHGYTPAEVQLSKRIMRYWANFARTGNPNKQFPDGDD
TESIVWPEYTAHEKEYLVISTNDSSIGRGLRAKQCAFWKNFLPKLINALENRHNSTCTSH
SNQIGSSNWSLAISLISLIMCFLPSLR [Tetranychus urticae]
Targeted Disease Candida infection
Drug Resistance Mutations
Mutation info Missense: G119S [1]
Mutation info Missense: F290V [1]
Target Name Tetranychus urticae Acetylcholinestrerase (Ace1) Target Info
Gene Name ace1
Uniprot ID Q86CZ4_TETUR
Species Tetranychus urticae
Reference Sequence MVPMFNHNINHFNNVIVTTLTHHQYTNSRCNSNNNVIKRITNSILKSVTVFTVKTLWNHL
LVPIVVILLFQSSANVFSSALPHSEINSFHADGPSSSSSFNSEHHHHHHHNDPLVVLTKK
GYVRGRSVVSPTGKPVDAFLGIRYAKPPTGKFRFRHPKPIDSWQGIFNATSFSGACYQVN
DTFFGNFMGATEWNPNVPLDEDCLSVNIWVPRPRPKSAAVLLWIYGGSFWSGSSSLDFYD
GSVLAGEESIIFVSINYRVASLGFIFFDTSDAPGNAGLFDQLMAMEWIRENIAAFGGNPA
NITIFGESAGAVSAALHLLSPLSRNVFSQAILQSGSATCPWAISDRKKAYQRSLALAQAV
GCGSTSTRSVHAIIECMQSIPASELVAQEETTTGVVEFAFIPIVDGSFLDEDPEVSLRTK
NFKHTPILTGSNRDEGTYFLVYHSPHIFNLSEGIYISRSEFQSLIRIIYPHLSPLAQEAV
IQEYTHWINPDDQIENREATDKFVGDYHFTCPVNEMSYRYALYGNDVWTYHFTHRSSKSF
WPSWMGVIHGEEIKFVLGEPLDPVHGYTPAEVQLSKRIMRYWANFARTGNPNKQFPDGDD
TESIVWPEYTAHEKEYLVISTNDSSIGRGLRAKQCAFWKNFLPKLINALENRHNSTCTSH
SNQIGSSNWSLAISLISLIMCFLPSLR [Tetranychus urticae]
Targeted Disease Candida infection
Drug Resistance Mutations
Mutation info Missense: A201S [2]
Mutation info Missense: F331W [2]
Mutation info Missense: F331Y [2]
Mutation info Missense: G119S [2]
Mutation info Missense: G328A [2]
Mutation info Missense: T280A [2]
References
REF 1 Insecticide resistance to organophosphates in Culex pipiens complex from Lebanon.Parasit Vectors.2012 Jul 3;5:132.
REF 2 Global distribution and origin of target site insecticide resistance mutations in Tetranychus urticae.Insect Biochem Mol Biol.2014 May;48:17-28.

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