Drug General Information
Drug ID D0D4YZ
Drug Name PSI-7977
Synonyms 1190307-88-0; SOVALDI; PSI 7977; GS-7977; GS 7977; UNII-WJ6CA3ZU8B; WJ6CA3ZU8B; CHEBI:85083; Sofosbuvir (PSI-7977, GS-7977); Hepcvir; Hepcinat; HSDB 8226; 2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester; Sofosbuvir [USAN:INN]; Resof; SoviHep; Sovaldi (TN); Sofosbuvir (JAN/USAN); Sofosbuvir(PSI-7977); GTPL7368; SCHEMBL2010114; CHEMBL1259059; AMMD00019; EX-A389; MolPort-028-720-482; isopropyl (2S)-2-[[[(2R,
Drug Type Small molecular drug
Company Gilead Sciences
Structure D0D4YZ
Drug Resistance Mutations
Target Name HCV RNA-directed RNA polymerase (NS5B) Target Info
Gene Name NS5B
Uniprot ID POLG_HCVJA(2420-3010)
Species Hepatitis C virus genotype 1b
Reference Sequence SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHSMVYSTTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKARLLSIEEACKLTPPHSAKSKFGYGAKDVRSLSSRAVNHIR
SVWEDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQAVMGPSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRTEESIY
QCCDLAPEARQAIRSLTERLYVGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT
AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETVRHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAATCGKYLFNWAVKTKLKLTPIP
AASQLDLSGWFVAGYNGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR [Hepatit
is C virus genotype 1b]
Targeted Disease HCV infection
Drug Resistance Mutations
Mutation info Missense: S282T [1]
Level of Resistance Confer 9.5 fold resistance
References
REF 1 Lam, A.M. et al. Selection and characterization of heaptitis C virus replicons using combinations of NS3 protease and NS5B non-nucleoside inhibitors or combination of NS5B nucleotide inhibitors. . in International HIV & Hepatitis Virus Drug Resistance Workshop, Vol. 15 Supplement 2 A28 (Dubrovnik, Croatia, 2010).

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