Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D06ZQK | ||||||||||
| Drug Name | Nucleozin analog 3061 (FA-2) | ||||||||||
| Drug Resistance Mutations | |||||||||||
| Target Name | Influenza RNA-directed RNA polymerase catalytic subunit (PB1) | Target Info | |||||||||
| Gene Name | PB1 | ||||||||||
| Uniprot ID | RDRP_I34A1 | ||||||||||
| Species | Influenza A virus | ||||||||||
| Reference Sequence |
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGRWTTNTE TGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVD KLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMKKEEMG ITTHFQRKRRVRDNMTKKMITQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRA IATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSF TITGDNTKWNENQNPRMFLAMITYMTRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESK SMKLRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIEGTASLSPGMMMGMFNMLSTVLG VSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKK KSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLG PATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYN IRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESMNNAVMMPAHGPAKNMEYDAV ATTHSWIPKRNRSILNTSQRGVLEDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVS RARIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK [Influenza A virus] |
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| Targeted Disease | Influenza infection | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.Proc Natl Acad Sci U S A.2010 Nov 9;107(45):19151-6. | ||||||||||
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