Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D04WFL | ||||||||||
| Drug Name | Trastuzumab | ||||||||||
| Synonyms | Herceptin; Herceptin (TN); Trastuzumab (INN); Trastuzumab (genetical recombination); Trastuzumab (genetical recombination) (JAN); Trastuzumab (ERBB2 mAb inhibitor) | ||||||||||
| Drug Type | Antibody | ||||||||||
| Therapeutic Class | Anticancer Agents | ||||||||||
| Company | Roche; Genentech | ||||||||||
| Drug Resistance Mutations | |||||||||||
| Target Name | RAC-gamma serine/threonine-protein kinase (ATK3) | Target Info | |||||||||
| Gene Name | AKT3 | ||||||||||
| Uniprot ID | AKT3_HUMAN | ||||||||||
| Species | Homo sapiens | ||||||||||
| Reference Sequence |
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE [Homo sapiens] |
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| Targeted Disease | Breast cancer | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | AKT signaling in ERBB2-amplified breast cancer. Pharmacol Ther. 2016 Feb;158:63-70. | ||||||||||
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