Drug General Information
Drug ID D03WHC
Drug Name Nnrti
Drug Resistance Mutations
Target Name HIV Non-Nucleoside reverse transcriptase Target Info
Uniprot ID POL_HV1B1(600-1159)
Species Human immunodeficiency virus type 1 (HIV-1)
Reference Sequence PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKIL [Human immunodeficiency virus type 1 (H
IV-1)]
Targeted Disease HIV infection
Drug Resistance Mutations
Mutation info Missense: G190S [1]
Mutation Frequency 8 out of 58 samples
Mutation info Missense: H221Y [1]
Mutation Frequency 9 out of 58 samples
Mutation info Missense: K101E [1]
Mutation Frequency 5 out of 58 samples
Mutation info Missense: K103N [1]
Mutation Frequency 14 out of 58 samples
Mutation info Missense: V108I [1]
Mutation Frequency 4 out of 58 samples
Mutation info Missense: Y181C [1]
Mutation Frequency 18 out of 58 samples
References
REF 1 Human Immunodeficiency Virus-1 Sequence Changes and Drug Resistance Mutation Among Virologic Failures of Lopinavir/Ritonavir Monotherapy: AIDS Clin... Open Forum Infect Dis. 2016 Aug 24;3(3):ofw154.

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