Drug General Information
Drug ID	D03JAF
Drug Name	Nrti
Drug Resistance Mutations
Target Name	HIV Non-Nucleoside reverse transcriptase				Target Info
Uniprot ID	POL_HV1B1(600-1159)
Species	Human immunodeficiency virus type 1 (HIV-1)
Reference Sequence	PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKIL [Human immunodeficiency virus type 1 (H IV-1)]
Targeted Disease	HIV infection
Drug Resistance Mutations	Mutation info Missense: D67N [1] Mutation Frequency 5 out of 46 samples
	Mutation info Missense: K65R [1] Mutation Frequency 5 out of 46 samples
	Mutation info Missense: M184V [1] Mutation Frequency 27 out of 46 samples
	Mutation info Missense: T215Y [1] Mutation Frequency 5 out of 46 samples
	Mutation info Missense: T69D [1] Mutation Frequency 4 out of 46 samples
References
REF 1	Human Immunodeficiency Virus-1 Sequence Changes and Drug Resistance Mutation Among Virologic Failures of Lopinavir/Ritonavir Monotherapy: AIDS Clin... Open Forum Infect Dis. 2016 Aug 24;3(3):ofw154.

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