Drug General Information
Drug ID D03END
Drug Name Insecticide
Drug Resistance Mutations
Target Name Carboxylic ester hydrolase (Est7) Target Info
Gene Name Est7
Uniprot ID Q95ZE4_DROYA
Species Fruit fly
Reference Sequence MYIPKRLLCLTLLWIAASGAEDPLLVEIPNGKLRGRDNGQYYSYESIPYAEPPTGALRFE
APQPYSHRWTDVFDATQSPVACLQWNQFRNENNKLMGNEDCLTVSIYKPKTPSRSSFPVV
VLLHGGAFMFGSGNIYGHDYIMREGQLLLVKISYRVGPLGFASTGDRDLPGNYGLKDQRL
ALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFRQLAKGAISVSGNALDPWVI
QQGGRRRAFELGRIVGCGQTNVSSELKDCLKSKPASEIVSAVRSF [Fruit fly]
Drug Resistance Mutations
Mutation info Missense: G137D [1]
References
REF 1 The same amino acid substitution in orthologous esterases confers organophosphate resistance on the house fly and a blowfly. Insect Biochem Mol Biol. 1999 Aug;29(8):675-86.

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