Drug General Information
Drug ID D02OZK
Drug Name Obatoclax
Synonyms CHEMBL408194; UNII-QN4128B52A; QN4128B52A; SCHEMBL631676; SCHEMBL16340850; BDBM50376902; ZINC136873052; DB12191; NCGC00387855-01; BRD-K15600710-066-01-7
Drug Type Small molecular drug
Company Cephalon
Structure D02OZK
Drug Resistance Mutations
Target Name SFV Envelope glycoprotein 1 (E1) Target Info
Gene Name E1
Uniprot ID Q87046_SFV
Species Semliki forest virus (SFV)
Reference Sequence YEHSTVMPNVVGFPYKAHIERPGYSPLTLQMQVVETSLEPTLNLEYITCEYKTVVPSPYV
KCCGSSECSTKEKPDYQCKVYTGVYPFMWGGAYCFCDSENTQLSEAYVDRSDVCKHDHAS
AYKAHTASLKAKVRVMYGNVNQTVDVYVNGDHAVTIGGTQFIFGPLSSAWTPFDNKIVVY
KDEVFNQDFPPYGSGQPGRFGDIQSRTVESNDLYANTALKLARPSPGTVHVPYTQTPSGF
KYWLKEKGTALNTKAPFGCQIKTNPVRAMNCAVGNIPVSMNLPDSAFTRIVEAPTITDLT
CTVATCTHSSDFGGVLTLTYKTDKNGDCSVHSHSNVATLQEATAKVKTAGKVTLHFSTAS
ASPSFVVSLCSAKATCSASCEPPKDHIVPYAASHSNVVFPDMSGTALSWVQKISGGLGAF
AIGAILVLVVVTCIGLRR [Semliki forest virus (SFV)]
Targeted Disease Mosquito borne viral fever
Drug Resistance Mutations
Mutation info Missense: L369I [1]
References
REF 1 Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments. Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02227-16.

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