Drug General Information
Drug ID D00YCO
Drug Name Pulvomycin
Synonyms Pulvomycin; AC1NQZFA; C12070; 11006-66-9; CHEBI:29668
Drug Type Small molecular drug
Structure D00YCO
Drug Resistance Mutations
Target Name Bacterial Elongation factor Tu (EF-Tu) Target Info
Gene Name EF-Tu
Uniprot ID EFTU_PEPD6
Species Peptoclostridium difficile
Reference Sequence MAKAKYERTKPHVNIGTIGHVDHGKTTLTAAITKTLYDRYQLGEAVDFANIDKAPEERER
GITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSATDGPMPQTREH
ILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLTEYDFPGDDTPIVRGSALMAL
EDPKSEWGDKIVELFEQIDEYIPAPERDTDKPFLMPVEDVFSITGRGTVATGRVERGVLK
VQDEVELVGLTEAPRKVVVTGVEMFRKLLDQAQAGDNIGALLRGVQRNEIERGQVLAKTG
SVKAHTKFTAEVYVLKKEEGGRHTPFFDGYRPQFYFRTTDVTGACKLPEGIEMVMPGDNV
TMEVDLINSIVVEEGLRFSIREGGRTVASGVVATIIE [Peptoclostridium diff
icile]
Drug Resistance Mutations
Mutation info Missense: R231C [1]
Mutation info Missense: R231V [1]
Mutation info Missense: R234F [1]
Mutation info Missense: R234S [1]
Mutation info Missense: R334C [1]
Mutation info Missense: T335A [1]
References
REF 1 CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.

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