Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99884 | Target Info | |||
| Target Name | HUMAN toll-like receptor 7/9 signalling pathway (TLR7/9 pathway) | ||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Opioid receptor sigma 1 (OPRS1) | Successful Target | ||||
| UniProt ID | SGMR1_HUMAN | |||||
| Gene Name | SIGMAR1 | |||||
| Synonyms |
hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8
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| Representative Drug(s) | Hydroxychloroquine | Drug Info | Ki = 125.89 nM | [1] | ||
| Co-Target Name | Sigma intracellular receptor 2 (TMEM97) | Clinical trial Target | ||||
| UniProt ID | SGMR2_HUMAN | |||||
| Gene Name | TMEM97 | |||||
| Synonyms |
Transmembrane protein 97; Sigma2 receptor; Sigma-2 receptor; Meningioma-associated protein 30; MAC30
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| Representative Drug(s) | Hydroxychloroquine | Drug Info | Ki = 1000 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9. | ||||
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