Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99041 | Target Info | |||
| Target Name | HUMAN dipeptidyl peptidase 4 (DPP-4) | ||||
| Synonyms |
Tcell activation antigen CD26; TP103; T-cell activation antigen CD26; Dipeptidyl peptidase IV; Dipeptidyl peptidase 4 soluble form; DPP-IV; DPP IV; DPP 4; CD26; Adenosine deaminase complexing protein-2; Adenosine deaminase complexing protein 2; ADCP2; ADCP-2; ADABP
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| Gene Name | DPP4 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Muscarinic acetylcholine receptor M1 (CHRM1) | Successful Target | ||||
| UniProt ID | ACM1_HUMAN | |||||
| Gene Name | CHRM1 | |||||
| Synonyms |
M1 receptor
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| Representative Drug(s) | Linagliptin | Drug Info | IC50 = 295 nM | [1] | ||
| Co-Target Name | Prolyl endopeptidase FAP (FAP) | Clinical trial Target | ||||
| UniProt ID | SEPR_HUMAN | |||||
| Gene Name | FAP | |||||
| Synonyms |
Integral membrane serine protease; Fibroblast activation protein alpha; FAP; Antiplasmin-cleaving enzyme; APCE; 170-kDa melanoma membrane-bound gelatinase
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| Representative Drug(s) | Linagliptin | Drug Info | IC50 = 70.8 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1464-8. | ||||
| REF 2 | Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2016 Mar 12;7(5):498-501. | ||||
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