Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T98933 Target Info
Target Name Thyroid hormone receptor beta (THRB)
Synonyms
c-erbA-beta; c-erbA-2; THR1; Nuclear receptor subfamily 1 group A member 2; NR1A2; ERBA2
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Target Type Successful Target
Gene Name THRB
Biochemical Class Nuclear hormone receptor
UniProt ID
THB_HUMAN
Co-Targets of This Target  Top
Co-Target Name Thyroid hormone receptor alpha (THRA) Successful Target
UniProt ID THA_HUMAN
Gene Name THRA
Synonyms
V-erbA-related protein 7; THRA2; THRA1; Nuclear receptor subfamily 1 group A member 1; NR1A1; ERBA1; EAR7; EAR-7; C-erbA-alpha; C-erbA-1
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Representative Drug(s) tiratricol Drug Info IC50 = 0.14 nM Click to Show More [1]
2 Axitirome Drug Info Ki = 40 nM [2]
References  Top
REF 1 Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1. J Med Chem. 2003 Apr 24;46(9):1580-8.
REF 2 Design, synthesis, and structure-activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptor beta (TRbeta) selective agonists. Bioorg Med Chem. 2013 Feb 1;21(3):592-607.

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