Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98494 | Target Info | |||
| Target Name | Galanin receptor (GAL-R) | ||||
| Synonyms |
GALR; GALNR; GAL-R
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| Target Type | Clinical trial Target | ||||
| Gene Name | GALR1; GALR2; GALR3 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | 5-HT 4 receptor (HTR4) | Successful Target | ||||
| UniProt ID | 5HT4R_HUMAN | |||||
| Gene Name | HTR4 | |||||
| Synonyms |
Serotonin receptor 4; 5-hydroxytryptamine receptor 4; 5-HT4 receptor; 5-HT4; 5-HT-4
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| Representative Drug(s) | HT-2157 | Drug Info | Ki = 72 nM | [1] | ||
| Co-Target Name | Galanin receptor 3 (GALR3) | Co-Target | ||||
| UniProt ID | GALR3_HUMAN | |||||
| Gene Name | GALR3 | |||||
| Synonyms |
Galanin receptor type 3; GAL3-R; GALR-3
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| Representative Drug(s) | HT-2157 | Drug Info | Ki = 17 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3757-8. | ||||
| REF 2 | Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3950-4. | ||||
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