Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T98311 Target Info
Target Name HUMAN angiotensin-converting enzyme (ACE)
Synonyms
Kininase II; Dipeptidyl carboxypeptidase I; DCP1; DCP; CD143 antigen; CD143; ACE
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Gene Name SLC33A1
Biochemical Class Glycosylase
UniProt ID
ACE_HUMAN
Co-Targets of This Target  Top
Co-Target Name Angiotensinogenase renin (REN) Successful Target
UniProt ID RENI_HUMAN
Gene Name REN
Synonyms
Renin; Angiotensinogenase
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Representative Drug(s) Captopril Drug Info Ki = 1.7 nM [1]
Co-Target Name Coagulation factor IIa (F2) Successful Target
UniProt ID THRB_HUMAN
Gene Name F2
Synonyms
Prothrombin; Coagulation factor II
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Representative Drug(s) Captopril Drug Info Ki = 48 nM [2]
Co-Target Name Leukotriene A-4 hydrolase (LTA4H) Successful Target
UniProt ID LKHA4_HUMAN
Gene Name LTA4H
Synonyms
Leukotriene A4 hydrolase; Leukotriene A(4)Leukotriene A-4 hydrolase hydrolase; Leukotriene A(4) hydrolase; LTA4; LTA-H; LTA-4hydrolase; LTA-4 hydrolase
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Representative Drug(s) Captopril Drug Info IC50 = 70 nM [3]
References  Top
REF 1 Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. J Med Chem. 1981 Apr;24(4):355-61.
REF 2 Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31.
REF 3 Probing the inhibition of leukotriene A4 hydrolase based on its aminopeptidase activity. Bioorg Med Chem Lett. 1991;1(10):551-6.

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