Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T98293 Target Info
Target Name PAK-4 protein kinase (PAK4)
Synonyms
p21-activated kinase 4; Serine/threonine-protein kinase PAK 4; PAK-4; KIAA1142
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Target Type Clinical trial Target
Gene Name PAK4
Biochemical Class Kinase
UniProt ID
PAK4_HUMAN
Co-Targets of This Target  Top
Co-Target Name PAK-1 protein kinase (PAK1) Literature-reported Target
UniProt ID PAK1_HUMAN
Gene Name PAK1
Synonyms
p65-PAK; p21-activated kinase 1; Serine/threonine-protein kinase PAK 1; PAK-1; Alpha-PAK
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Representative Drug(s) PF-3758309 Drug Info IC50 = 13.7 nM [1]
Co-Target Name PAK-2 protein kinase (PAK2) Literature-reported Target
UniProt ID PAK2_HUMAN
Gene Name PAK2
Synonyms
p21-activated kinase 2; Serine/threonine-protein kinase PAK 2; S6/H4 kinase; PAK65; PAK-2; Gamma-PAK
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Representative Drug(s) PF-3758309 Drug Info IC50 = 190 nM [1]
Co-Target Name Serine/threonine-protein kinase PAK 6 (PAK6) Co-Target
UniProt ID PAK6_HUMAN
Gene Name PAK6
Synonyms
PAK-5; p21-activated kinase 6; PAK-6
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Representative Drug(s) PF-3758309 Drug Info IC50 = 17.1 nM [1]
Co-Target Name Serine/threonine-protein kinase PAK 5 (PAK5) Co-Target
UniProt ID PAK5_HUMAN
Gene Name PAK5
Synonyms
p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7
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Representative Drug(s) PF-3758309 Drug Info IC50 = 18.1 nM [1]
Co-Target Name Serine/threonine-protein kinase PAK 3 (PAK3) Co-Target
UniProt ID PAK3_HUMAN
Gene Name PAK3
Synonyms
Beta-PAK; Oligophrenin-3; p21-activated kinase 3; PAK-3
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Representative Drug(s) PF-3758309 Drug Info IC50 = 99 nM [1]
References  Top
REF 1 Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015 May 22;6(7):776-81.

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